Mechano Growth Factor MGF

MGF is a variant of IGF-1, an isoform that is particularly sensitive to muscle trauma (weight training) and is essential for repair and growth of new cells, similar in manner to IGF-1. What you need to know is MGF triggers new cell growth or hyperplasia in rat testing, and since we as bodybuilders fancy ourselves as lab rats, it is currently the in vogue peptide by top amateurs and pros.

Well all of this sounds great but what is the catch? This is where we reach a cross-road, a potential problem with MGF. As great as MGF has been in clinical trials and rat studies, the fact is that injected MGF has a half life of minutes. So how are you going to make this work, besides injecting every hour or so of your waking day? The answer lies in a little known molecule protection agent knows as PEGylation.

So what is or PEGylation? In simple terms it is the process of attaching one or more chains of a substance called polyethylene glycol (PEG) to a protein molecule such as IGF or in this case MGF. Since the body does not react to PEG, it helps provide a protective barrier around an attached protein so it can survive in the body longer. This is highly beneficial for systemic products that must survive repeated attacks by enzymatic exposure. PEG is an inert non-toxic substance that can provide protection to amine groups since they are flexible and allow attachment by bioengineered processes to the receptor bearing cell. Finally a quick explanation of polyethylene glycol; Any of a family of high molecular weight compounds that can be liquid or wax-like in consistency and are soluble in water and in many organic solvents.

Polyethylene glycol itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG.

PEGylation can improve dosing convenience of many small molecules by increasing bioavailability and reducing dosing frequency. PEGylation also increases the amount of time the cell sits at the target site. This can be both good and bad. It is good because it increases the drug concentration, and with a longer time at the site, there is more chance of uptake by the cell. The bad news is that while it is sitting at the cell, there is increased risk of damage by enzymes that attack the cell. This is a double-edge sword that is a necessary evil; you must protect the molecule but at the same time increase the risk factor of damage due to longer exposure times at the target cell. As a result of the increased time at the cell, the optimal drug concentration can be achieved with less frequent dosing; a significant benefit to bodybuilders who are usually using poly-pharmacy at its finest.

PEGylated MGF is systemic in nature, meaning that the method of administration is not important. Most people are using MGF in a fashion similar to IGF, meaning they inject the peptide intramuscularly in recently trained muscle groups, hoping for an increase in cell repair and proliferation of new cells. While this thinking is optimistic at best, there is no research that would support site specific injections being beneficial for localized growth. This is a myth that has purveyed aas and peptide use for years. At this time, the literature and lab studies support subcutaneous injection, using small gauge insulin syringes.

Obviously there are no human research trials at this time; the peptide is still in research phases. Bodybuilder use at this time is all by trial and error. One company that currently carries MGF has conducted their own research trials, using test participants from underground steroid boards who are providing feedback in weekly intervals. While this is hardly a controlled environment and may have to many variables to accurately assess the product, at least it is a start.

I have also been conducting my own research, on myself and my clients, who often refer to themselves as Gavin's guinea pigs. As with most peptides, more is not better. Smaller doses with less frequent injection schedules have proven to be optimal. I personally have been using 200mcg injected sub-q, two times per week. I have had my clients try 100mcg, two times per week, three times per week, daily, etc. So far the best results have been my personal method, 200mcg, two times per week.

Elite athletes are experiencing incredible body fat loss, increased pumps, fullness, and vascularity. I was able to gain 6 pounds of lean mass and lose 4.2% body fat in 4 weeks of use. I kept using it for weeks 5 and 6 but with no further gains or body fat loss. It seems that MGF stalls out at the 4 week mark, my theory being that much like with media grade IGF-1 LR3, the cells reach super saturation and cannot process any further uptake of the peptide sequence. It is possible to bypass this saturation, but it will take some time to work out the differential nature of the timing, much like I had to do with IGF-1 LR3, where I have now found ways to take it for up to 20 weeks with little to no cell down-regulation.

At this time all use and injection schedules are by word of mouth, sometimes by erroneous information on underground boards. Proper use of MGF is merely by speculation; it will take some time to sort out the best method of administration, although with the ever changing world of science, where nothing ever stands still, it may take years to sort out optimal dosing schedules. Even with such stable peptide structures as growth hormone that have had years of research, new information is always being studied, and I speculate that it will with all peptides.

What is Testosterone Suspension?

Testosterone Suspension is an injectable preparation of pure, un-modified and un-esterified Testosterone, almost always suspended in a water base within microcrystals (hence the name Testosterone Suspension). Within the bodybuilding and athletic world, Testosterone Suspension is regarded as the most potent and strongest form of injectable Testosterone available, and it is known for producing some of the most rapid mass, strength, and physique changes out of all injectable preparations of Testosterone. This is for several reasons. The first reason is because this is the purest form of Testosterone, unmodified and unesterified, meaning it is instantly active the minute it is injected into the body. Also, because there is no added ester bonded to the Testosterone molecule, there is more total Testosterone per mg of Testosterone Suspension, making it a far more potent product. Because ester weights must be factored into the total weight of the substance, esterified formats of Testosterone (or any hormone) such as Testosterone Propionate, Testosterone Enanthate, and Testosterone Cypionate do not all yield 100mg of Testosterone in 100mg of Testosterone Enanthate, for example. Once the body cleaves off the ester that is bound to the molecule, the weight of the ester is removed, and so for example, in 100mg of Testosterone Enanthate, there is in reality approximately 70mg of Testosterone. 100mg of Testosterone Suspension, however, yields exactly 100mg of Testosterone. Because esterified variants of Testosterone have longer half-lives and require their esters to be removed (before releasing pure Testosterone), optimal peak blood plasma levels are achieved often in weeks of use. This is not the case with Testosterone Suspension, where optimal peak blood plasma levels are achieved in a matter of hours instead.

For example, it takes approximately 4 or 5 weeks (some users even report as late as 6 weeks) of use of the longer Testosterone esters, such as Testosterone Enanthate and Cypionate, before mass and strength gains are experienced. With Testosterone Suspension, gains are normally experienced within the first week of use, and by 4 weeks into a Testosterone Suspension cycle, the bulk of the gains will usually have been achieved (meanwhile by this same time period, the longer acting formats of Testosterone will only just have begun taking effect).

Properties of Testosterone Suspension

Testosterone has always been known to promote large amounts of nitrogen retention in muscle tissue, with studies indicating significant increases in fat-free mass and muscle size as a result. Testosterone is also well-known for its ability to significantly increase levels of IGF-1 (Insulin-like Growth Factor 1) in muscle tissue, which further contributes to significant increases in muscle size and strength. A study on Testosterone’s action within muscle tissue indicated that this primarily occurs through its ability to activate satellite cells in muscle tissue, which is very important in the role of repairing damaged muscle fibers. That same study also indicated that Testosterone exhibits the ability to inhibit adipogenesis (the storage of fat) as well as the ability to increase the size of motor neurons. Testosterone has been found to achieve its muscle growth and strength-promoting effects primarily through the interaction with the androgen receptor located in muscle cells as one of its primary mechanisms. Androgens such as Testosterone also increase red blood cell count via a stimulation of the increase of Erythropoietin in the kidneys, resulting in better oxygen transport throughout the body, thus increasing the endurance capabilities of the athlete.

Testosterone in general is regarded as one of the best mass-adding and bulking agents. Those who wish to bulk up will experience more rapid results with the use of Testosterone Suspension than with any other form of Testosterone. It has also been found that there is a relationship between the dose used and the amount of muscle growth whereby the higher the dose, the greater the growth experienced. Testosterone is what would be considered as the original anabolic steroid, manufactured naturally and endogenously within all humans and in most animal species. Testosterone Suspension can be utilized for any particular goal, as Testosterone is the most versatile anabolic steroid.

Daily and Weekly Timing of Oral Anabolic Steroids

How to time the use of oral anabolic steroids during the day or week?

For anabolic effect, it’s most efficient for levels to be as sustained as possible across the day, within reason. We could compare, for example, taking Dianabol as 50 mg once per day or as 10 mg five times per day.

On the once-daily dosing, you’d have about a 5 or 6 hour period with blood levels as high or higher than in the multiple-dosing case. But for the rest of the day, levels would be lower, usually far lower. For the last 10 hours or more, they’d be uselessly low.

Now that might work fine if the very high levels of the first few hours multiplied the effect during that period, but that’s not the case. Ongoing 10 mg dosing already about maximizes the effect of Dianabol.
During the earlier part of the day the two dosing plans give about the same activity as with the frequent lower dosing, but for most of the day the once-daily plan gives less activity.

It doesn’t take a full 5 times per day to give a good result. For Dianabol, I think 3x/day is reasonable as a minimum, though personally I prefer 4x or 5x/day.

Oxandrolone (Anavar), oxymetholone (Anadrol), and stanozolol (Winstrol) all have longer half-lives than Dianabol does. As a result, they may be dosed less frequently. For these, 2x/day is a reasonable minimum, though I prefer 3x or 4x/day.

As for which days of the week should receive orals, again sustained levels are the most efficient, where the only purpose is anabolism. Using orals every day is best. However, some like taking orals pre-workout and relying only on injected steroids for the rest of the week. Where the choice of injected anabolic steroids is sufficient and suitable by itself, then this is fine.

But if the steroid stack depends on the orals, then use the orals every day. It’s entirely acceptable though to shift timing of orals to pre-workout and/or post-workout if you wish, or to add orals at those times. When adding orals at these times, total daily dosage should still be kept within typical amounts.

In some cases the purpose of orals is increased training aggression. When used for this, make sure the rest of the steroid stack will work by itself as intended, and then use orals for best effect pre-workout.