How To Prevent Estrogen Effects with GP Anastrozole by Geneza Pharmaceuticals

GP Anastrozole is an oral aromatase inhibitor manufactured by Geneza Pharmaceuticals. It was created for adjutant therapy of postmenopausal women with hormone receptor-positive early breast cancer. GP Anastrozole is a true aromatase inhibitor which works by blocking the aromatase enzyme in the body, thus limiting the amount of estrogen buildup that takes place.

Another use of anastrozole for men is to maintain a powerfully-built and bulky physique among bodybuilders, especially those who take anabolic steroids. One function of steroids is that it mimics the actions of naturally occurring testosterone, resulting in the increase of protein levels, muscle buildup, and strength improvement. Ironically, the excessive levels of testosterone and testosterone-like drugs signal the body to convert the male hormones into estradiol, which can lead to development of female features such as breasts and fat retention. Bodybuilders counter this hormone conversion by using anastrozole, but usage is often mishandled and may produce more adverse effects.

In studies that have been done, Anastrozole has been shown to reduce estrogen in the body by roughly 50%. This is a good balance for bodybuilders, because some estrogen is needed in order for the full anabolic benefits of the steroids being taken to be achieved.

It is wrong to think, however, that estrogen and its effects (particularly water and fat retention) are absolutely detrimental to bodybuilding. Remember that this hormone is also responsible for muscle strength and gains. Consequently, it minimizes the occurrence of injury as it improves the ability of muscle fibers to withstand contractile tension or stress. Notice that one of the side effects of Anastrozole use is the likely occurrence of fractures, a major drawback of this drug. This is because when Anastrozole effectively blocks the formation of estrogen, it effectively blocks the benefits of this hormone as well. This is why many still decide for estrogen receptor antagonists like Nolvadex and Clomid because these drugs allow some estrogen activity in the body.

Further, aromatase inhibitors like Anastrozole have the tendency to completely suppressed estrogen activity, including its positive effect on cholesterol levels in the body. Anastrozole is known to decrease HDL what is commonly known as the 'good' cholesterol. Typically, bodybuilders using GP Anastrozole will begin taking it the day they start their cycle, and will run it throughout the duration of steroid administration. It is also important to point out GP Anastrozole's ability to increase testosterone in the body. Some studies have shown that natural testosterone levels have increases as much as 60% after the use of this substance for 7 days. Because of this, bodybuilders find this drug extremely effective during PCT where as they are trying to elevate natural levels as much as possible in order to avoid a post cycle "crash".

Daily dosage for males is from 0.5mg to 3mg. For women, a maximum dosage of 1mg per day is enough to combat estrogenic side effects. Because Anastrozole has a short active life, dosages are usually taken two to six times a day at equal intervals. During PCT, athletes normally start with higher dosage then implement a progressive decrease in dosage. The PCT protocol typically runs for seven to 14 days. In clinical studies, it has been observed that a daily dose of 1 mg of this drug results to more than 80% of estrogen suppression.

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IGF-1 and IGF-2 Peptides Hormones

Insulin-like growth factors 1 and 2 (IGF-1, IGF-2) are peptides that are similar in amino acid sequence and structure to insulin and can bind to the insulin receptor having the same glucose lowering effect1. IGF-1 and 2 also binds to the type 1 IGF receptor and are largely responsible for the growth promoting effects of growth hormone. The Type 1 IGF receptor also binds insulin but with lower affinity and is likely responsible for the anabolic effects of insulin beyond those of glucose uptake. There is a type 2 receptor but it only binds IGF-2 and does not appear to be involved with the anabolic effects of IGF-2. IGF-2 has largely been ignored as a promoter of skeletal muscle anabolism but since it signals through the same receptor as IGF-1, it will produce similar anabolic responses.

IGF-1 binds to the type-1 receptor which acts through a cascade of transcription and differentiation factors such as AKT, glycogen synthase kinase 3-beta (GSK-3b), mammalian target of rapamycin (mTOR), myoD and others to increases amino acid uptake and protein synthesis and decreases nitrogen excretion while stimulating the differentiation of satellite cells which can result in growth not only of skeletal muscle but also of internal organs such as the spleen, liver and heart. Circulating IGF-1 is produced by the liver in response to stimulation by growth hormone. IGF-1 in skeletal muscle is produced locally and stimulates hypertrophy and hyperplasia locally in what is referred to as a paracrine action. When produced locally, IGF-1 is often modified to form a slightly different protein called mechano-growth factor or MGF. Testosterone stimulation of the androgen receptor has been shown to result in local production of IGF-1 in skeletal muscle.

IGF-1 circulates in the plasma bound to a family of binding proteins. These binding proteins extend the half-life of IGF-1, which is usually very short. They also transport IGF-1 to target cells and modulate the action of IGF-1. There are six known IGF binding proteins. Under most conditions, IGF binding proteins seem to inhibit IGF-1 activity, probably by reducing the free concentrations available for binding. IGFBPs also inhibit IGF-1 activity by competing with IGF-1 receptors for IGF-1 binding. IGFBP3 can interact directly with cell membranes (possibly through a receptor of its own) to inhibit the action of IGF-1 and to exert effects of its own. IGFBP5 is widely considered to be a potentiator of IGF-1 action, probably by delivering IGF-1 to its receptor. Androgens increase IGFBP5 levels while reducing IGFBP3 levels which further suggests that IGFBP3 is a negative regulator if IGF-1 activity while IGFBP5 is a positive regulator. IGFBP4 has been shown to be an inhibitor of IGF-1 anabolic action in skeletal muscle.

It is no wonder that such a potent anabolic is being used illicitly to try to enhance muscle strength and size. Recombinant IGF-1 in various forms is available for research purposes and though it is not intended for human consumption, users have been experimenting with it for quite some time. Some have attempted to inject recombinant IGF-1 subcutaneously but the quantities needed and the short half-life result in minimal efficacy. Local intramuscular injections seem to produce some local anabolic effect but again, the short half-life limits its utility. A variant form of IGF-1 called Long R3 IGF-1 that has minimal binding to IGF binding proteins and a longer half-life has been used to promote anabolism. The down side to this particular form of IGF-1 is that it circulates at high levels in an unbound form. Circulating IGF-1 has been shown to be associated with tumor progression while IGF binding proteins (particularly binding protein 3) have been shown to protect against tumor progression, likely through restricting the actions of IGF-1. Another form of IGF-1 that has been proposed as an anabolic agent is des(1-3)IGF-1. This shortened form of IGF-1 is incapable of being bound by IGF-1 binding proteins and is much more potent in stimulating hyperplasia in skeletal muscle. Injected locally, this peptide may have better growth promoting properties than native IGF-1. The use of IGF-1, especially in a systemic fashion, will result in decreased natural production of GH.

The IGF system is complex with multiple ligands and binding proteins whose roles are not fully understood. The IGF-1/AKT pathway has been demonstrated not just to promote growth in skeletal muscle but also in internal organs and to play a role in the progression of cancer suggesting that this pathway must be carefully regulated to prevent serious side effects. The fact that these peptides are not scheduled and are available in a pseudo-legal fashion makes them much more available than AAS but with a potentially much higher liability profile. This is one of the unfortunate unintended consequences of the criminalization of AAS.

GHRP-6 and Peptide Hormone Craze

It seems everyone is raving on peptide hormones as the amazing 'new thing' in lazy, drug-induced muscle growth and fat loss. The fact is, injectable peptide hormones have been around for decades. The diabetic hormone Insulin is a peptide hormone and it was first available in the 1920's!

When Peptides Came To Fame
But Growth Hormone (GH) was the peptide hormone that changed everything. GH was credited to creating the new era of muscular bodybuilding monsters from around the time Lee Haney arrived in the 80's. And demand for the drug - and its reputation as being THE underground 'secret of the pros' - was bolstered by its mind-blowingly expensive price and rarity.

Then IGF-1 hit the black market before it was even an approved drug and the mystery and rumors surround GH, Insulin and IGF reached fever pitch. Steroids were old news. Now, if you want to look like a pro bodybuilder you just need to get enough of the right peptides.

GHRP-6
Which brings us to GHRP-6. GH Releasing Peptide is cheap and... well, currently not illegal to purchase over the internet. As the name suggests, it causes GH release; so people figure it must be exactly the same as GH and therefore will make them look like a pro bodybuilder in no time, with no effort and without all the rest of the drugs. Unfortunately, you won't look anything like a pro bodybuilder from using GHRP-6. The only reason it is so HUGELY popular is because finally Mr Average can AFFORD something that looks like the hardcore 'gear' the pro's use... except not.

I don't know anybody who got anything out of GHRP-6 whatsoever! At least, nothing over and above what might be expected from the other 'things' they were doing/taking at the time. In fact, when really pressed, nobody I know seems to know of anybody else who got any great benefit out of it either. All of the guys I know who still use it only do because it is cheap and they don't want to risk not taking it, 'in case it helps'.

So Why Use It?
Everybody knows that pro bodybuilders use lots of drugs and, these days, are as lazy as sin in the gym. The conclusion for many people is that drugs or injecting/boosting your naturally occurring hormones is the only way to build muscle.

Supplements are selling like crazy in response to the belief that the solution to an awesome physique is in a bottle. And if your muscles don't arrive you don't blame your hopeless training or disgraceful diet. You just got the wrong bottle of magic potion.

Many young guys will inject anything they possibly can afford and get and then strangely believe they are transforming into a pro bodybuilder just by being so 'hardcore' as to be taking a drug. I knew a guy who kicked in the door of his own car in a claimed 'roid rage' only minutes after injecting himself with some cooking oil that he thought was a steroid.

When Peptides Become Relevant to Bodybuilding Training
It all comes back to what I've always said: its all about your training. Train and diet properly and a drug-free athlete should be able to achieve about a 260kg deadlift before things become extremely hard to go further. If you can't get a natural 260kg deadlift then you are training and eating wrong. Some guys can even acheive a 260kg deadlift without ever actually doing a deadlift or training hard!

But if the physique of a lean 260kg deadlifter is not muscular enough for you (eg typically around 95kg at 8% bodyfat at 180cm) then you are going to probably need unnatural means to achieve your unnatural goals. Very low dose, testosterone optimisation therapy can help a successfully training athlete to achieve a 300kg deadlift and a great physique (eg around 105kg at 8% at 180cm).

If you still want more unnatural levels of muscle then you probably need to break the law and cycle higher doses of testosterone and/or add GH. Beyond a 340kg deadlift (growing bigger than around 115-125kg at 8% at 180cm) you'll probably need to stay on higher doses of steroids year round.

By the time you reach the muscularity capable of a 360kg deadlift (ie over 130kg, lean at 180cm) as a career-criminal steroid user, then progress will probably be determined by cycles of insulin with GH and IGF-1 and all the rest.

This is the point at which these peptide growth factors become relevant: the pro-bodybuilder level. Without the heavy base of steroid hormones, though, they are a mostly a waste of time and money. And if you are already using all of these drugs to achieve a lesser physique then you need to take a serious look at yourself, your diet and your training!

The Importance of Testosterone Inclusion in Every Cycle

It is a well-known set-in-stone rule that Testosterone is such an essentially important hormone that it must be included as the primary base compound in every single cycle as either a primary anabolic compound, or at the very least as a supportive compound in the role of TRT. A ‘primary anabolic compound’ is defined as a compound within a cycle that acts as one of the primary contributors to muscle accrual, and must usually be run at supraphysiological bodybuilding doses to do so. A perfect example is a cycle consisting of Testosterone and Dianabol (Methandrostenolone) in which Testosterone is run at 500mg per week alongside Dianabol at 30mg per day. In such a case, both compounds are utilized at bodybuilding doses (supraphysiological doses), and are therefore acting as primary anabolic compounds. A cycle consisting of Testosterone, Dianabol, and Proviron (Mesterolone) at doses of 500mg/week (Testosterone), 30mg/day (Dianabol), and 25mg/day (Proviron) is a display of Proviron not acting as a primary anabolic while the other two compounds do. The role if Proviron in this case is that of a supportive compound, as it is run at a dose too low to be considered a ‘bodybuilding’ dose, and Proviron itself is not a very strong anabolic compound by any measure.

The use of Testosterone in a cycle that includes, for example, Testosterone at 100mg/week, Trenbolone at 400mg/week, and Masteron (Drostanolone) at 400mg/week is the perfect example of a cycle in which Testosterone is not a primary anabolic compound. In this case, Testosterone then takes upon a supportive role of TRT (Testosterone Replacement Therapy) in order to merely maintain normal physiological levels of Testosterone during a period in which the body’s own endogenous production of Testosterone will be suppressed and/or shut down (as a result of the anabolic steroid cycle). This is a perfect description of the use of Testosterone at TRT doses during cycles, and this concept, as well as the reasons behind it, will be further expanded upon slightly very shortly in this article. Whichever the individual’s decision may be, the concept that Testosterone must be run in every single cycle is a basic stipulation of proper and responsible anabolic steroid use. It is a basic rule that Testosterone must be included in every cycle run – there are no exceptions to this rule.

Why Must Testosterone Be Included In Every Cycle?
Testosterone is, quite plainly, the original anabolic steroid; it is the body’s primary androgen that is necessary for a myriad of proper physiological functions. It is a hormone that is manufactured naturally inside all humans and the majority of animal species. It is because of this that Testosterone is considered the safest anabolic steroid, as mentioned many times throughout this article. It cannot be stressed enough that this is because it is the hormone within each human being that is already secreted, already utilized, and is already accustomed to. The logic then follows that the use of Testosterone for the purpose of performance and physique enhancement is easily described as the act of presenting greater amounts of a hormone that the body already secretes and utilizes into the body in order to maximize levels of these hormones for a temporary period (a cycle).
It is through this logic that it has also been determined, as a solid ground rule to anabolic steroid use, that every single first cycle for should always be a cycle of Testosterone-only (any selected variant of Testosterone) as their very first cycle. Testosterone-only cycles introduce the user to a safer anabolic steroid (Testosterone) that the human body has been previously accustomed to naturally for many years prior, as all human beings previously manufacture and utilize Testosterone endogenously. What this opens for the individual anabolic steroid user is the ability to gauge their reaction to the most basic anabolic steroid, Testosterone. It is the result of this gauging procedure that the user can assess his potential reactions and responses to other anabolic steroid analogues and derivatives. This is because the rationale behind the process dictates that there is a high probability that if an individual responds nastily in various undesirable manners to a basic Testosterone cycle, then there will likely be a greater probability of the individual responding in an even worse manner to the majority of other anabolic steroids, which of course are essentially modified analogues of Testosterone.

Illegal Steroids

Anabolic steroids are the steroids of particular interest that receive all of the negative attention in the media and on the television. They are the illegal steroids in the United States and a few other nations in the world, while other types of steroids are not illegal at all in most Western countries. The legality of anabolic steroids varies quite a bit, with relatively few countries imposing very strict control on them while in the vast majority of countries they are not illegal. In the United States, illegal steroids are placed under the Schedule III category of controlled substances under the Controlled Substances Act (CSA), which was originally imposed via the Anabolic Steroid Control Act of 1990. This makes the posession, use, distribution, manufacture, buying, and selling of illegal steroids a felony with criminal punishments. Illegal steroids in the UK are classified as Class C controlled drugs by way of the Misuse of Drugs Act, which was enstated on November 1st, 1996. In the UK, it is not illegal to possess or use anabolic steroids, but it is illegal to manufacture, supply, sell, or import licensed approval. In Canada, almost the exact same is true where illegal steroids are permitted for personal possession and use, but the sale, distribution, importation, and manufacture is illegal. This is made possible by virtue of the fact that anabolic steroids in Canada are classified as Schedule IV substances under the CDSA (Controlled Drugs and Substances Act) of Canada, whereby any items classified under Schedule IV are permitted for personal use and possession, but not for the reasons previously stated.

The rest of the world expresses very few or no laws in regards to anabolic steroids. Only a very small handful of countries in the world have adopted laws towards illegal steroids that are as draconian as the United States, with perhaps a handful in Western Europe. This also includes Australia, Argentina, Brazil, and Portugal, where illegal steroids hold generally the same status as in the United States (any and all forms of possession outside of prescription use is deemed criminal). Otherwise, those steroids that are typically deemed ‘illegal steroids’ in the United States or other similar Western nations, are not illegal in the rest of the world. An example of a couple of countries where anabolic steroids are freely and legally available without a prescription are Mexico and Thailand, which are common locations whereby individuals will purchase and consume anabolic steroids, and are also known as popular hubs for the black market illegal steroid trade.

What Makes Illegal Steroids Illegal?

The concept of anabolic steroids being illegal is a very relative one, and it is very relative to the United States, which is the very first nation that has expounded the idea that anabolic steroid use is necessarily a bad thing, and subsequently pressured other nations into siding with its anti-steroid sentiment. The reason for anabolic steroids obtaining the legal status that it has in the United States (and the West in general) is an extremely deep and rich subject that could be debated for ages on end. Illegal steroids have been deemed as such for many difference reasons, ranging from the claims that they provide an unfair advantage in professional sports to the supposed claims concerning the negative health effects. Some might claim that the justifications for the legal status of anabolic steroids in the United States are absent and void of any validity, while there are staunch supporters that the public must be protected from the abuse of these drugs. Whatever the case may be, it is very evident that the moral justifications for the legal status of anabolic steroids are very grey ones. For example, a close look at the records of the discussions and debates on the hearing floors of the Congressional hearings on anabolic steroids in 1990 will reveal the fact that the overwhelming majority of the pages of transcripts are filled with discussion concerning their ability to enhance athletic performance. This comes as quite a surprise considering the public is constantly told by the government and the media that the sole reason for the criminalization of anabolic steroids is to control the health risks associated with their use. 

Fat Loss Steroids

One of the most common questions asked is; what are the best fat loss steroids? Anabolic steroids, which will lead to a greater reduction in body fat than others do exist actually. Whilst it can be said that all anabolic steroids will aid in fat loss, some are better than others at this action. But it should be understand all anabolic steroids, whether oral or injectable can be put in the same category as fat loss steroids. In other sections of this site we have discussed some of the most popular steroids in existence, some of which, can be classified as fat loss steroids, as apposed to anabolic steroids more inept to putting mass or lean tissue on the users frame. Some of the other more popular drugs or agents used primarily for fat loss are not actually fat loss steroids, but other drugs and compounds thought to be anabolic steroids.

What Are Fat Loss Steroids?

Fat loss steroids can be steroids that increase or decrease a number of bodily functions or factors that can mean the user burns more fat. These mechanisms vary, but in the simplest of terms anabolic steroids that either increase muscle mass (most do) or those that reduce adipose tissue can be classified as fat los steroids. But that doesn’t really tell us much as all anabolic steroids would be in this group. So in simple terms:

    The more muscle mass we carry the more calories we burn
    Anabolic steroids increase lean body mass (LBM)
    Added mass increases energy expenditure

Almost all anabolic steroids can yield the above anabolic effects, but some can directly reduce excess body fat. These anabolic steroids can be classified as fat loss steroids and some are more effective than others. You may or may not already be familiar with Trenbolone or Winstrol (Stanozolol) by now, but these two along with Anavar are some of the most popular anabolic steroids ever used. These steroidal agents are primarily used for fat loss, although Trenbolone can be used as part of a mass gaining cycle or phase. Al three anabolic steroids have a large impact on fat cells, although each also increases muscle mass at varied degrees. These three steroids are often part of a bodybuilders cutting cycle or when leading to competition. Anabolic steroids that are also excellent and more favourable compounds for fat reduction, other anabolic steroids do exist that can also be known as fat loss steroids.

These below steroids are commonly part of cutting cycles as opposed to bulking, mass or offseason steroid stacks.

    Winstrol (Stanozolol)
    Boldenone Unddeclynate (Equipoise)
    Trenbolone
    Anavar (Oxandrolone)
    Primobolan (Methenolone)
    Masteron (Drostanolone)
    Testosterone (Sustanon, Enanthate, Cypionate, Propionate)

Drugs Not Fat Loss Steroids

Some of the most popular compounds that are thought to be steroids, or somewhat affiliated to anabolic steroids, are those attributed to fat loss. If it’s not in the group of above discussed anabolic steroids, its simply not a steroid, but another drug. These include mostly stimulants and other thermogenics as well as Human Growth Hormone. Although its often referred to as the steroid black market, this market involves the illegal sale and distribution of many other drugs, performance enhances and ancillaries. From SERMs (selective estrogen receptor modulators), such as, Nolvadex, to dopamine agonists, such as, Cabergoline, the market is full of other performance enhancing agents. So its easy to confuse a stimulant, such as, Clenbuterol as an anabolic steroid, or fat loss steroid in this instance. Its not and neither are a group of other drugs.

    Clenbuterol (Clen)
    Albuterol
    Ephedrine
    Cytomel (T3)

The above are stimulants, whilst Cytomel (T3) is a synthetic thyroid hormone. These drugs often have medical benefits, such as, the treatments for asthma, hypertension, shock and hyperthyroidism. These drugs are not fat loss steroids, but are inherently used for the reduction of adipose tissue or excess body fat. In fact, these drugs are probably more effective than fat loss steroids, but this comes down to personal preference. Stimulants increase energy expenditure, lipolysis and fat oxidation, similar to fat loss steroids, but their action of these processes is more magnified than anabolic steroids.

Human Growth Hormone is another compound often thought to be an anabolic steroid but isn’t. Its actually a peptide hormone and is a potent weapon against unwanted excess fat. HGH is often used as part of a long cycle containing both fat loss steroids or bulking steroids, depending on the users goals. One thing is for sure, HGH needs to be run for months, not weeks, if lean muscle mass is the objective or fat loss is wanted. Fat loss from Human Growth Hormone can be like no other fat loss steroid or stimulant when run correctly. 

Masteron vs Equipoise – Which is Better to Gain Muscle?

Is Masteron or Equipoise the better steroid to gain muscle? The answer depends on how it’s being looked at.

Effectiveness milligram per milligram: One way is, having the rest of a stack already, and wanting to add X mg of boldenone, or the same mg of Masteron. To some extent it would depend on what the rest of the stack was, but in most cases I’d call this a pretty even match.

Cost per milligram: Another would be, having the rest of a stack already, and having $X to spend on either boldenone or Masteron. Usually the answer would be, whichever is cheapest per mg. I think this would usually be the boldenone but not always.

Side effects: Still another would be, having the rest of a stack already, and picking appropriate doses for each drug, considering side effects. Depending on preferences or on the rest of the stack, Masteron would win in many cases; boldenone in some others.

When looking at side effects, it’s always necessary to look at the sum total of the stack. Too often an individual component gets blamed, when the problem is that that the total was simply too much, and omission of another of the compounds would also have avoided the problem.

Don’t think Masteron is the slightest bit worse than anything else when it comes to hair loss or effect on the prostate for any given amount of anabolic effect. But if you had what was a substantial steroid dosage already and then added another steroid to it, the total could easily be more than personally suitable for you.

However if you used it alone and found it unsuitably harsh for you, that would be a different story. That would be unusual though: I’ve never encountered it.

Single steroid stack: THEN you have the question of using by itself.

If mass is the only consideration and if only one can be picked, boldenone. Not recommended as the way to gain the most mass in either case.

If mass is the only consideration and there’s the option of using both: Using both.

It was Masteron propionate 100 mg/day, boldenone propionate 50 mg/day, so just over a gram per week total. Nice. Nothing wrong with it at all, I’d be fine with doing it again.

The enanthates would have been more convenient as it was an 8 week cycle and would be fine, but propionates were what was on hand.