GP T3 Trijodthyronin or Cytomel by Geneza Pharmaceuticals

GP T3 (Trijodthyronin, Cytomel) is a thyroid hormone designed and developed to treat hypothyroidism. Hypothyroidism is simply a condition where adequate thyroid hormone(s) are not being produced; commonly this can be caused by an iodine deficiency, as well as pituitary malfunction among other causes but it is a condition that is quite common. Through the use of GP T3 (Cytomel) we can increase the amount of thyroid hormones we have in our body, most notably the Triiodothyronine hormone commonly known as T3. The Triiodothyronine hormone is responsible for many functions, most notably metabolic activity but it also plays a role in bodily growth and the heart among many others. As T3 is produced by the pituitary gland its mode of action in terms of development and release is regulated by the thyroid-stimulating hormone (TSH.) Once thyroid hormones both T3 and T4 reach a certain level in the blood production is decreased as increased levels block TSH from being released; however, once the levels fall TSH is again released and more T3 and T4 is produced. By supplementing with GP T3 (Cytomel) we actively increase the amount of T3 in our body far beyond what natural TSH will allow.

The Benefits of GP T3
With a simple understanding of T3 hormone its benefits should come quite easily. By taking Cytomel we increase the amount of T3 in our body, by increasing the amount of T3 in our body we increase metabolic activity; by increasing metabolic activity we increase the rate in-which we burn fat. When we look at it in its most simplistic terms it is just that, rather simple; however, to fully understand the benefits of Cytomel we must understand the full effects of the T3 hormone which are quite vast and affect many various areas. While these affects are vast we are only largely concerned with how they affect metabolic activity; however, it’s effects can stretch to even the heart as increased levels of the T3 hormone increase cardiac output

By taking GP T3 (Cytomel) we greatly increase protein efficiency; however, we also increase the rate in-which protein is broken down. Due to this fact adequate amounts of protein must be taken in but this is good news as even though we require more than normal each gram is now being utilized to a far greater degree. Further and this is of the greatest importance, when we take Cytomel we increase the rate in-which glucose is metabolized by increasing the rate in-which glycogen is broken down. The faster this occurs the sooner the body is required to rely on stored body-fat for an energy source. Further and of equal importance, by taking Cytomel we increase the rate in-which cholesterol is broken down; all of these things greatly aid in increasing the rate of lipolysis.

The Side-Effects of GP T3 (Cytomel)
As is with all medications GP T3 (Cytomel) does carry with it potential negative side-effects, however many of the side-effects commonly associated with this medication are of little truth but some do exist. The blatant obvious negative effect is undoubtedly the loss of muscle tissue; as many performance enhancing athletes use GP T3 (Cytomel) in an aid to lose body-fat they do so on a calorie restricted diet, because of this low consumption of calories, if adequate amounts are not in place muscle tissue will be burned. For this reason, a performance enhancing athlete will never take GP T3 without anabolic steroids, ignoring this rule will assuredly result in the loss of a vast amount of lean tissue. Beyond this possible negative side-effect others do exist but they prove to be very individualistic, dose dependent and in many cases very rare. Possible side-effects include most commonly, headaches, insomnia and excess sweating. Many women who use Cytomel may also find their menstrual cycles disrupted, however, this is often to be expected when body-fat becomes extremely low.

The GP T3 (Cytomel) Myths
A common myth revolving GP T3 (Cytomel) is that it will damage your thyroid production beyond repair and while it is possible for this myth to hold a small amount of truth it is generally far exaggerated and borne of fear. While extreme Cytomel use for an extreme amount of time may have a damaging effect there is no hard proof, however, we do know that Cytomel can be used for decent lengths of time, up to nearly a year with no permanent damage being done to the thyroid. However, most will never find a need to use any thyroid medication for this extended period of time unless they already suffer from some level of permanent thyroid damage. Nevertheless, make no mistake, the use of GP T3 (Cytomel) will prevent your thyroid from producing its own natural T3 hormone but it will recover full capabilities in most all cases in a mere 2-3 months once use is discontinued and often sooner in some individuals.

GP T3 (Cytomel) Doses & Cycles
We have established that as a performance enhancing athlete GP T3 (Cytomel) is to only be used in conjunction with anabolic steroids and never alone as use alone will in-fact result in a loss of muscle tissue. With this in mind the next question is when is the best time to use? It should go without saying that during cutting cycles such as a competitive bodybuilding cycle is the best time to use this medication and common practice is to use GP T3 (Cytomel) the final 6 weeks of competition to get rid of that last bit of fat; however, it can be successfully used for the entire duration of a diet but one will need to keep an eye on tissue loss if this path is taken. For most a cycle of GP T3 that is in the 6-8 week range will prove to be all the GP T3 (Cytomel) they’ll ever need. As for the amounts, generally 25mcg per day is a good place to start with increases of 12.5mcg being applied as needed. This protocol includes GP T3 cycles for both men and women; however both will necessarily keep the dose as low as possible and only increase as needed. Most men can increase their dose safely to 150mcg per day while women will necessarily keep a maximum dose at 100mcg per day. In either case, learn to listen to your body, learn how to accurately observe your body and the effects and if you do you’ll find your GP T3 use to be more enjoyable and effective. There is a final note that will prove to provide a great benefit in thyroid recovery after use is discontinued; easing into recovery is far more beneficial than a cold turkey stop. There is no need to gradually ramp down but rather simply drop your dose down to the original starting point of 25mcg every day and hold for approximately two weeks. By following this method you will ensure your thyroid begins production sooner than later.

Five things you didn’t know about peptides

Used by amateur athletes the new generation of performance and image enhancing peptides have rapidly grown in familiarity over recent months, but how much do you really know about them?

As the “drugs in sports” debate continues, we take one step back from the scandal to answer the core questions in an effort to correct the common misconceptions about peptides and their general use.

What are peptides?

Essentially, peptides are just very short proteins. Unlike the majority of proteins that provide the building blocks for cells or get chewed up for energy, a select few of these peptides actually “communicate” with cells and act as hormones.

Peptide hormones, like all other hormones, travel through the blood stream to all corners of the body. Many peptides are inert and do practically nothing; some interact with very specific tissues in the body (like the brain and your skin) and only a small handful have metabolic, image and/or performance enhancing effects.

A popular group known as growth hormone releasing peptides (or GHRPs) are examples of hormones that tell the body to produce more natural growth hormone, helping men and women to essentially gain muscle and lose fat. Different variations of peptide hormones have theoretical side-effects, like increased appetite, but very few have been legitimately researched in any form in human clinical trial.

According to a recent report by the Australian Crime Commission (ACC), the market for performance and image enhancing drugs (PIEDs) in Australia is large and diverse extending across a broad cross-section of the community.

With this widespread use of PIEDs across Australia, it’s important that some very key questions are asked and addressed. Below are what I consider to be the five most common and incorrectly answered questions.

One. Are peptides “anabolic steroids”?

Regardless of what you may have heard in the locker room, peptides are not anabolic steroids. Peptides are made up of amino acids just like any other protein. Steroids (anabolic/contraceptive/anti-inflammatory) are hormones too but it’s practically just a coincidence that a very small group of peptides causes anabolic effects like “anabolic steroids” do. The associated risk in peptide therapies is the orised to be much lower than that of testosterone-derived (anabolic) steroids however no injections are ever without risk.

Two. Are peptides illegal?

Although you won’t find many peptide hormones on the TGA’s current Poisons Schedule (where steroids and other illicit drugs of abuse are listed) peptides are slowly being added to this growing list with each periodical instalment. Depending on where they eventually land on the list, some are prohibited to be sold without prescription whilst others are illegal to have in possession at all.

Up until early February this year, peptide hormones and other performance-enhancing drugs were freely available to anyone with an internet connection and a credit card. The TGA has now moved to prevent the supply of these hormones online without a prescription.

Peptide use in sports is another issue altogether. Most peptide hormones have been explicitly blacklisted by the World Anti-Doping Authority (WADA) and are absolutely prohibited in numerous sporting codes. This is where the media has focused their attention and why a dark shadow has been cast across many sports both in Australia and overseas.

Three. Are all peptides performance-enhancing drugs?

Some peptide hormones can improve athletic performance. Performance-enhancing drugs (PEDs) can take many forms. Any compound which improves an athlete’s ability to outperform his or her competitors in an unfair manner technically falls under this umbrella term. A weight-loss drug can help a MMA fighter unfairly improve body composition before weigh-ins just like stimulants can improve a sprinter’s split.

Not all peptide hormones interact with muscles or metabolism in a way that would improve athletic performance. Some peptides communicate solely with other tissues. As an example, Melanotan is a peptide which causes the skin to produce more pigment and is not a drug likely to improve athletic prowess.

Four. Are peptides used in medicine?

Of the better understood peptide variants, one growth hormone related peptide - AOD-9604 - has recently found itself injected into the mainstream media - as well as Brownlow medallist Jobe Watson according to his recent admission. AOD-9604 was developed by researchers to combat obesity by increasing metabolic breakdown of stored fats and is likely to possess therapeutic potential in Australia’s obesity epidemic.

In response to the enormous threat presented by type-II diabetes in the Middle East, pipe-lined peptide products were revealed at the International Congress in Aesthetic and Anti-ageing Medicine (ICAAM) in Dubai last year. These peptide hormones are being developed not only to improve body composition but to restore insulin sensitivity – the key pathology implicated in the onset of type-II diabetes.

Five. Are peptides safe?

Although peptides are still accessible through countless “here-one-minute, gone-the-next” online stores, there are two serious issues that potentially endanger those entrusting these sites:

    According to a presentation by the TGA, many of the under-researched peptides being sold online have the potential to cause severe immune reactions and;
    Although some companies may be producing these products in the proper facilities, there are no guarantees or regulating bodies that ensure the products found online are legitimate, safe and free from bacterial contamination.

Legitimate pharmaceutical-grade peptides with proven efficacy and safety are slowly making their way to Australian pharmacies as a result of thorough clinical trials. However, it’s more than likely that your physician will always be the one to have the final say as to whether the potential benefits of these drugs outweigh the potential risks.

What is Melanotan and What does it do?

Melanotan-II was first created at The University of Arizona as a possible way to help people ward off skin cancer. Melanotan-II is formulated in a lab and is a reproduction of a hormone that human body naturally produces called melanocyte-stimulating hormone. This hormone helps the body’s natural pigmentation become active and produce tanned skin. It takes about two weeks for the skin to tan and the effects last only if the substance is administered regularly. After many studies, it was stated that the effects of the synthesized Melanotan-II injection did not last long enough, and the FDA, as well as many other countries medical approval systems denied Melanotan-II as being effective for tanning and cancer prevention. So, researchers decided to find another possible way of utilizing the formulated product.

Palatin Technologies jumped on the opportunity to discover new uses for the synthetic hormone and were able to distill another similar-like human hormone called Bremelanotide. Bremelanotide, while in its proper name, is still referred to as  Melanotan-II is now administered as an injection to produce erections in men with ED (erectile dysfunction), as well as for people who would like to have a tanned look. The results for men with erectile dysfunction are quite impressive. One study showed that seventeen out of twenty men, who were injected with Melanotan-II, became aroused and the average erection lasted about four hours and had a high rigidity. The hormone does not just produce erections, it also sustains sexual arousal and desire in men. Sounds like a winne

So, if you are looking to have longer, harder erection, while having a stronger sex drive, plus the effect of looking tan, then Melanotan-II is the drug for you. It is meant for men who have erectile dysfunction or a lower libido, so if you feel you could use a little more pep in your step Melanotan-II is the way to go.
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IGF-1 - the Benefits of Insulin-Like Growth Factor-1

IGF-1 Builds Muscle
Some bodybuilder's are saying they have put on up to 20 lbs of muscle mass. There are no independent clinical study results to support this claim, but the evidence is increasing. Some say they have dropped 5% body fat in only one month of therapy, while at the same time increasing their strength and lean muscle.

Dr. Di Pasquale, who is an expert in anabolic steroids and performance-enhancing compounds believes that HGH taken with IGF-1 works better due to the feedback mechanism between the growth hormone in the pituitary gland and the IGF-1 in the liver.

He notes that growth hormone causes the release of IGF-1, but when levels reach a certain point, the pituitary gland ceases to release HGH. There is a delay, however, in this process which means that HGH levels increase at night and IGF-1 levels increase during the day. Bodybuilders are taking both together in order to receive the best possible benefits.

The Effectiveness of Homeopathic IGF-1
Homeopathic IGF-1 also works in many different areas of the body to facilitate and improve cellular performance. A recent independent double-blind, placebo-controlled clinical study demonstrated effectiveness in the nervous, reproductive, musculoskeletal, and gastrointestinal systems.

Specifically, homeopathic IGF-1 improved energy levels and physical performance, and it improved respiratory conditions and relieved symptoms of PMS and menopause. It also relieved muscle and bone aches and pains, joint stiffness, inflammation in the body, improved mental concentration and clarity, and positively affected appetite.

Increases in lean body mass have been reported. Homeopathic IGF-1 balances weight by helping the body to achieve its ideal weight, whether that means losing fat for people too heavy, or gaining lean muscle for people too lean. It is believed to bring aging, resting cells back into a balanced state.

The Human Body's Growth Factor Army
IGF-1 is only one of the body's many growth factors that are now being identified, isolated, and cloned using genetic engineering technology for use as drugs. Eric Dupont, Ph.D., says that HGH is the general and IGF-1 and growth factors are the foot soldiers." IGF-1 and growth factors function similarly to hormones, however hormones usually send long distance messages and IGF-1 and the growth factors usually send local messages.

FULL BODY TRAINING FOR POWER AND STRENGTH

SO YOU WANT TO BE THE BIGGEST, strongest guy in your gym? This workout will go a long way to elevating you to such a lofty status. Follow this routine to the letter while continually trying to use heavier and heavier pound ages as your body adapts, and you won’t be able to help but grow like on steroids.
>> Many of these exercises work multiple major muscle groups at once (for example, the first move hits your thighs, delts and core), and they build explosive strength at the same time.
>> While we’ve stressed slow in this power routine you want to “explode” through the positive contraction. For example, on the decline barbell press, bring the bar down carefully to your chest, then push as hard and as quickly as you can to lift the bar straight up.


SQUAT JUMP-PUSH PRESS
START: Stand up straight holding dumbbells at shoulder level, so your palms face each other.
MOVE: Descend into a full squat and then explode upward, jumping out of the squat as you press the weights to full extension. As you land, lower the weights back to your shoulders, making sure to bend your knees to “catch” them smoothly. Descend immediately into another rep. The movement is continuous; you shouldn’t come to a stop until the set ends.

SQUAT–UPRIGHT ROW
START: Stand up straight holding a pair of dumbbells at arms’ length in front of your thighs, palms facing your body.
MOVE: Bend your knees until your thighs are parallel to the floor. As you descend, pull the dumbbells up to the level of your collarbones. Straighten your arms and legs simultaneously to return to the start position.

INWARD/OUTWARD ROTATION
START: Stand up straight holding dumbbells upright at your chest and shoulders, elbows bent and fists facing each other.
MOVE: Extend the dumbbells out to your sides and arc them together in front of you (your arms are still fully extended). Bend your elbows to pull the dumbbells back into your chest. Do 10 reps using this technique and, without stopping, do the same number of reps in reverse, pressing the dumbbells forward and then bringing them out to your sides in an arc.

How To Prevent Estrogen Effects with GP Anastrozole by Geneza Pharmaceuticals

GP Anastrozole is an oral aromatase inhibitor manufactured by Geneza Pharmaceuticals. It was created for adjutant therapy of postmenopausal women with hormone receptor-positive early breast cancer. GP Anastrozole is a true aromatase inhibitor which works by blocking the aromatase enzyme in the body, thus limiting the amount of estrogen buildup that takes place.

Another use of anastrozole for men is to maintain a powerfully-built and bulky physique among bodybuilders, especially those who take anabolic steroids. One function of steroids is that it mimics the actions of naturally occurring testosterone, resulting in the increase of protein levels, muscle buildup, and strength improvement. Ironically, the excessive levels of testosterone and testosterone-like drugs signal the body to convert the male hormones into estradiol, which can lead to development of female features such as breasts and fat retention. Bodybuilders counter this hormone conversion by using anastrozole, but usage is often mishandled and may produce more adverse effects.

In studies that have been done, Anastrozole has been shown to reduce estrogen in the body by roughly 50%. This is a good balance for bodybuilders, because some estrogen is needed in order for the full anabolic benefits of the steroids being taken to be achieved.

It is wrong to think, however, that estrogen and its effects (particularly water and fat retention) are absolutely detrimental to bodybuilding. Remember that this hormone is also responsible for muscle strength and gains. Consequently, it minimizes the occurrence of injury as it improves the ability of muscle fibers to withstand contractile tension or stress. Notice that one of the side effects of Anastrozole use is the likely occurrence of fractures, a major drawback of this drug. This is because when Anastrozole effectively blocks the formation of estrogen, it effectively blocks the benefits of this hormone as well. This is why many still decide for estrogen receptor antagonists like Nolvadex and Clomid because these drugs allow some estrogen activity in the body.

Further, aromatase inhibitors like Anastrozole have the tendency to completely suppressed estrogen activity, including its positive effect on cholesterol levels in the body. Anastrozole is known to decrease HDL what is commonly known as the 'good' cholesterol. Typically, bodybuilders using GP Anastrozole will begin taking it the day they start their cycle, and will run it throughout the duration of steroid administration. It is also important to point out GP Anastrozole's ability to increase testosterone in the body. Some studies have shown that natural testosterone levels have increases as much as 60% after the use of this substance for 7 days. Because of this, bodybuilders find this drug extremely effective during PCT where as they are trying to elevate natural levels as much as possible in order to avoid a post cycle "crash".

Daily dosage for males is from 0.5mg to 3mg. For women, a maximum dosage of 1mg per day is enough to combat estrogenic side effects. Because Anastrozole has a short active life, dosages are usually taken two to six times a day at equal intervals. During PCT, athletes normally start with higher dosage then implement a progressive decrease in dosage. The PCT protocol typically runs for seven to 14 days. In clinical studies, it has been observed that a daily dose of 1 mg of this drug results to more than 80% of estrogen suppression.

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IGF-1 and IGF-2 Peptides Hormones

Insulin-like growth factors 1 and 2 (IGF-1, IGF-2) are peptides that are similar in amino acid sequence and structure to insulin and can bind to the insulin receptor having the same glucose lowering effect1. IGF-1 and 2 also binds to the type 1 IGF receptor and are largely responsible for the growth promoting effects of growth hormone. The Type 1 IGF receptor also binds insulin but with lower affinity and is likely responsible for the anabolic effects of insulin beyond those of glucose uptake. There is a type 2 receptor but it only binds IGF-2 and does not appear to be involved with the anabolic effects of IGF-2. IGF-2 has largely been ignored as a promoter of skeletal muscle anabolism but since it signals through the same receptor as IGF-1, it will produce similar anabolic responses.

IGF-1 binds to the type-1 receptor which acts through a cascade of transcription and differentiation factors such as AKT, glycogen synthase kinase 3-beta (GSK-3b), mammalian target of rapamycin (mTOR), myoD and others to increases amino acid uptake and protein synthesis and decreases nitrogen excretion while stimulating the differentiation of satellite cells which can result in growth not only of skeletal muscle but also of internal organs such as the spleen, liver and heart. Circulating IGF-1 is produced by the liver in response to stimulation by growth hormone. IGF-1 in skeletal muscle is produced locally and stimulates hypertrophy and hyperplasia locally in what is referred to as a paracrine action. When produced locally, IGF-1 is often modified to form a slightly different protein called mechano-growth factor or MGF. Testosterone stimulation of the androgen receptor has been shown to result in local production of IGF-1 in skeletal muscle.

IGF-1 circulates in the plasma bound to a family of binding proteins. These binding proteins extend the half-life of IGF-1, which is usually very short. They also transport IGF-1 to target cells and modulate the action of IGF-1. There are six known IGF binding proteins. Under most conditions, IGF binding proteins seem to inhibit IGF-1 activity, probably by reducing the free concentrations available for binding. IGFBPs also inhibit IGF-1 activity by competing with IGF-1 receptors for IGF-1 binding. IGFBP3 can interact directly with cell membranes (possibly through a receptor of its own) to inhibit the action of IGF-1 and to exert effects of its own. IGFBP5 is widely considered to be a potentiator of IGF-1 action, probably by delivering IGF-1 to its receptor. Androgens increase IGFBP5 levels while reducing IGFBP3 levels which further suggests that IGFBP3 is a negative regulator if IGF-1 activity while IGFBP5 is a positive regulator. IGFBP4 has been shown to be an inhibitor of IGF-1 anabolic action in skeletal muscle.

It is no wonder that such a potent anabolic is being used illicitly to try to enhance muscle strength and size. Recombinant IGF-1 in various forms is available for research purposes and though it is not intended for human consumption, users have been experimenting with it for quite some time. Some have attempted to inject recombinant IGF-1 subcutaneously but the quantities needed and the short half-life result in minimal efficacy. Local intramuscular injections seem to produce some local anabolic effect but again, the short half-life limits its utility. A variant form of IGF-1 called Long R3 IGF-1 that has minimal binding to IGF binding proteins and a longer half-life has been used to promote anabolism. The down side to this particular form of IGF-1 is that it circulates at high levels in an unbound form. Circulating IGF-1 has been shown to be associated with tumor progression while IGF binding proteins (particularly binding protein 3) have been shown to protect against tumor progression, likely through restricting the actions of IGF-1. Another form of IGF-1 that has been proposed as an anabolic agent is des(1-3)IGF-1. This shortened form of IGF-1 is incapable of being bound by IGF-1 binding proteins and is much more potent in stimulating hyperplasia in skeletal muscle. Injected locally, this peptide may have better growth promoting properties than native IGF-1. The use of IGF-1, especially in a systemic fashion, will result in decreased natural production of GH.

The IGF system is complex with multiple ligands and binding proteins whose roles are not fully understood. The IGF-1/AKT pathway has been demonstrated not just to promote growth in skeletal muscle but also in internal organs and to play a role in the progression of cancer suggesting that this pathway must be carefully regulated to prevent serious side effects. The fact that these peptides are not scheduled and are available in a pseudo-legal fashion makes them much more available than AAS but with a potentially much higher liability profile. This is one of the unfortunate unintended consequences of the criminalization of AAS.