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Wednesday, May 28, 2014

Types of Steroids: Testosterone Derivatives

It is extremely important to understand that Testosterone is utilized as the measuring stick (or the measuring bar) whereby all other anabolic steroids are measured against, referenced with, and compared to (much like the celsius scale of temperature measurement where the freezing point and boiling points of water are used as the baseline measurements for temperature). Upon understanding this, any individual can easily observe how a particular given anabolic steroid possesses an anabolic strength that might be several times s

Testosterone Analogues Or Testosterone Derivatives

As previously mentioned in the latter part of the introduction, all anabolic steroids in existence could ultimately be considered derivatives/analogues of Testosterone, but there are several direct derivatives of Testosterone that exist. Derivatives of Testosterone will of course possess and exhibit some or many of the same properties of Testosterone, and this can present both advantages and disadvantages which will be explained and covered in detail here. The very first officially created Testosterone analogue is Methandrostenolone (Dbol), followed by Boldenone (Equipoise). These two analogues will be utilized here as examples.

The general characteristics of Testosterone derivatives are very similar to that of Testosterone: they all exhibit the ability to aromatize into Estrogen (a characteristic shared with Testosterone itself), and they all exhibit the ability to interact with the 5-alpha reductase (5AR) enzyme to become reduced to a stronger androgen. Although they do not reduce into Dihydrotestosterone like Testosterone does, they still interact with the 5AR enzyme and reduce to their own respective individual stronger androgens (Dianabol will reduce into Dihydromethandrostenolone and Boldenone will reduce into Dihydroboldenone). However, the reduction of these analogues into their respective stronger androgenic metabolites differs from Testosterone in that they are reduced into very small trace amounts (usually the result of the structural modifications allowing these anabolic steroid analogues to possess a lesser affinity to bind to the 5AR enzyme).

In terms of the actual structural modifications, we will first examine Dianabol (Methandrostenolone). Dianabol is basically Testosterone that has been methylated at carbon 17-alpha on its structure (this is simply the addition of a methyl group at the 17th carbon). This process, known as C17-Alpha Alkylation, allows the anabolic steroid to be administered orally and still have a measurably strong effect on the body. Without this modification, it is impossible for any anabolic steroid to survive liver metabolism in significant enough quantities to promote any measurable effects in the body – the result is that extremely miniscule amounts of the anabolic steroid reaches the bloodstream to perform its job. Dianabol also possesses a double-bond between carbons 1 and 2. All of these modifications are what grant Dianabol with its increases in anabolic strength and reduced androgenic strength in comparison to Testosterone.

Equipoise (Boldenone) is very easy to describe after understanding Dianabol. Equipoise is simply Dianabol without the methyl group attached to carbon 17-alpha. EQ possesses the double-bond between carbons 1 and 2. The fact that these two hormones operate very differently in the body is quite evident that is a very strong indication that the addition of a methyl group (C17-alpha alkylation) to the 17th carbon does more than just affect the hormone’s resistance to breakdown in the liver – it actually changes the effects and properties of the anabolic steroid. Dianabol itself possesses moderate Estrogenic activity in the body, while Equipoise possesses low Estrogenic activity in the body. It is very evident that the structural modifications to Testosterone that result in both Dianabol and Equipoise grant one of them lower Estrogenic activity than Testosterone itself, but does not eliminate it. This is an example of what has been mentioned earlier about various properties and traits passed down from the parent/progenitor hormone to the analogue/derivative hormone, and that sometimes it will not always be expressed exactly the same.

Testosterone analogues, because of their ability to still exhibit Estrogenic activity at some level, will commonly be preferred by users as anabolic steroids that are utilized in bulking or mass-gaining cycles due to the fact that the water retention associated with it is typically undesirable during periods of cutting or fat loss. This is because the water retention can cause the physique to take on a bloated and soft look. Therefore, the use of compounds such as Dianabol is generally limited as such. But this is not to say that Dianabol cannot be utilized for fat loss or cutting. Any anabolic steroid can be utilized for any purpose. There is no such thing as the commonly claimed myth of ‘cutting steroids’, ‘fat loss steroids’, ‘bulking steroids’, or ‘lean mass steroids’. There exist no such possible things except for anabolic steroids that may be preferred for cutting, bulking, or lean mass depending on their attributes and properties that are associated with side effects that may be undesirable for the goal of cutting or bulking. This will be further explained in greater detail in the final section of this article, but it is important to touch upon this topic and leave this idea in the reader’s mind for the time being.
tronger (or weaker) than Testosterone (Testosterone’s anabolic and androgenic ratings are both respectively 100). The importance of the anabolic and androgenic strength ratings of 100 respectively is paramount to understanding the different strengths of the various types of steroids.

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