GenezaMeds.com

GenezaMeds.com

Tuesday, July 29, 2014

The Many Benefits of Anavar

Anavar is a medication that people used to help them regain their weight after losing it due to some medical conditions like surgery, trauma and other chronic infection. It is also known to relieve pains caused by bone loss or osteoporosis. But aside from its medical benefits, Anavar is also popular because of its muscle enhancing effect. Athletes use this because it helps them increase their muscular strength while losing body fat. It is consider a natural anabolic steroid that provide quick positive results. To acquire this authentic steroid product, one can order Anavar from Thailand.

Anavar’s Benefits

A great pharmaceutical factory known as British Dragon is based on Thailand. The factory is the pioneer in terms of marketing Anavar. It was first made intended for building muscles. Bodybuilders are satisfied with the product’s fast results. Unlike other steroids, users also claim that it has no major side effects on them. It enhances their performance and provides them maximum effects. Proper dosage of Anavar can also aid a person in maintaining his ideal weight. But aside from its benefits in promoting bodybuilding, there are some who order Anavar from Thailand because of its ability to treat various diseases including AIDS. Researchers found out that this steroid can combat the effects of AIDS and helps in treating muscle loss that AIDS patients are suffering from. People who suffer from severe illness can also be treated with Anavar.

Proper Dosage for Maximum Effects

What sets Anavar apart from other steroids is that it is non-toxic. With proper dosage, an individual can achieve the steroid’s maximum benefit. Taking this product beyond the prescribed dosage may lead to extreme side effects and may even cause death. Users might acquire an addiction if the product is not properly administered. Most of us have this concept of steroids as harmful to the body because it made us produce more testosterone than the usual. However, this can only be true if we will abuse this product. Proper dosage and timing is crucial when taking steroids especially for medication purposes. Steroids like Anavar is safe to take if we will follow the prescribed dosage.

Look for Authentic Anavar

Consumer must also ensure that they are not purchasing fake steroids to avoid harmful side effects. It is safe to order Anavar from Thailand because one can be sure that it is authentic and of high quality. Accurate and legitimate Anavar tablets can be hard to find. Many counterfeiters replaced small amounts of other drugs in their Anavar product. Street dealers passed off lose pills of other cheaper steroids in placed of Anavar. Licensed pharmacies produces Anavar or Oxondrolone in 2.5mg tablets while black market sellers have their Anavar steroids come in 10mg tablets. These underground laboratories acquire patent for their product as 2.5mg.

Tuesday, July 22, 2014

SERMs: Nolvadex and Clomid in Post Cycle Therapy

Post cycle therapy (PCT) is perhaps the most important aspect of anabolic steroid use. The human body will normally restore this imbalance of hormones and recover its endogenous Testosterone levels on its own over time with no assistance, but studies have demonstrated that without the intervention of Testosterone stimulating agents, this will occur over the course of 1 – 4 months. This is quite evidently enough time for the hormonal imbalance to wreak havoc on the body and result in any individual losing most or all of the newly gained muscle during this time. Therefore, all anabolic steroid users should be concerned with the fastest possible hormonal recovery, assisted and boosted with the use of Testosterone stimulating compounds in the proper manner. Furthermore, the attempt to allow the body to recover on its own will present a very high probability of long-term endocrine damage to the HPTA over time whereby the individual will develop anabolic steroid induced hypogonadism (the inability to manufacture proper levels of Testosterone for the rest of their life). It is therefore paramount that a proper post cycle therapy that includes multiple recovery compounds be utilized so as to not only restore the HPTA function to normal levels as quickly as possible, but to avoid any possible permanent damage, which takes priority over the concern of maintaining the recently gained muscle mass.

SERMs: Nolvadex and Clomid

The question is often asked among the anabolic steroid using community: Clomid or Nolvadex? Which one for PCT?

First of all, the best possible addition to HCG in a PCT protocol is Nolvadex (Tamoxifen Citrate), as studies have demonstrated that HCG and Nolvadex utilized together have exhibited a remarkable synergistic effect in terms of stimulating endogenous Testosterone production, and that Nolvadex will actually work to block the desensitization effect on the Leydig cells of the testes caused by high doses of HCG. This is very important, because just as too little LH secretion for extended periods can cause desensitization to gonadotropins, too much gonadotropin stimulation (in the form of HCG or otherwise) will likewise cause a desensitization effect.

Questions HCGSecondly, Nolvadex on a mg for mg basis is far more effective than Clomid in stimulating endogenous Testosterone production, as well as being a more cost-effective choice than Clomid itself. Studies have demonstrated that 150mg of Clomid (Clomiphene Citrate) administered daily raised endogenous Testosterone levels of 10 healthy males by approximately 150%, while incidentally, 20mg of Nolvadex (Tamoxifen Citrate) daily raised endogenous Testosterone levels by the same amount. It is very evident here that Clomid is very effective for this purpose, but Nolvadex seems to be a more cost-effective choice seeing as though it is more effective than Clomid when compared mg for mg. The benefits of Nolvadex over Clomid do not end there – Clomid, although it does exhibit Estrogen antagonist effects at the pituitary gland like Nolvadex does, actually exhibits Estrogen agonist effects there too. What this means is that Clomid will actually work in varying degrees as an Estrogen at the pituitary gland, triggering the negative feedback loop and reducing the output of Testosterone stimulating gonadotropins (LH and FSH). This is a very serious problem during post cycle therapy, which is a period in which individuals are trying to recover their HPTA function rather than halt it even further. Ideally, one would want a SERM that exhibits almost 100% Estrogen antagonistic effects on the pituitary gland, and Nolvadex is the perfect choice for this.

When it comes to the dosing aspect of Nolvadex, The standard dose for PCT and for stimulating the release of GnRH (Gonadotropin Releasing Hormone), LH, FSH, and ultimately Testosterone is that of a simple Nolvadex dose of 20 – 40mg daily. In all studies involving Nolvadex doses used to stimulate endogenous Testosterone production, only 20 – 40mg daily of Nolvadex was utilized, and it has in fact been shown that doubling the dose to 40mg or any higher will not produce any significant difference in endogenous Testosterone secretion. The only reason why many elect to utilize 40mg daily of Nolvadex for the first 1-2 weeks of a PCT program is for the purpose of achieving optimal peak blood plasma levels quicker so as to ensure HPTA recovery quicker.

Tuesday, July 15, 2014

Fat loss and Triiodothyronine (T3)

Triiodothyronine, also known as T3, is most frequently used in the BB’ing community as a fat loss agent; a job it accomplishes quite effectively. In fact, no other compound used today, aside from perhaps DNP, has the potential to burn body fat more quickly. However, T3 is non-discriminatory when it comes to calorie burning and will pull calories from wherever necessary in order to meet the body’s increased energy demands, including muscle tissue. At appropriate dosages and under the correct conditions, this is not a concern, but at higher dosages its non-discriminatory nature places obvious restrictions on the drug’s ultimate fat burning potential, as most BB’rs are not willing to sacrifice their hard-earned muscle tissue in order to enhance the fat loss process. This is understandable, yet limitations notwithstanding, T3 remains one of the most versatile fat loss drugs on the market, finding a home in the programs of both pre-contest and off-season BB’rs alike.

Before moving on, let’s take a brief look at what T3 is and how it is made within the human body. As you’ve probably guessed, T3 (as well as T4) is a thyroid hormone produced by the thyroid gland. This small organ is located in the front of the neck and is regulated by the all-important hypothalamus, which is the primary control center for many of the autonomic functions of the peripheral system, including regulation of thyroid hormones. When levels of these hormones become low, the hypothalamus sends a signal to the pituitary gland, telling it to produce a hormone called TSH (thyroid stimulating hormone). This hormone then travels to the thyroid gland, communicating the message to produce T3 & T4. The thyroid’s sole job is the production of these hormones, which it accomplishes by combining iodine with the amino acid tyrosine (Fun fact: thyroid cells are the only cells in the human body capable of absorbing iodine).

Post-formation, the active hormones are then released into the bloodstream, where they serve as regulators of whole-body metabolism. Every cell in the body is dependent on these hormones for proper metabolic functioning, with even a slight deviation in levels resulting in potentially disastrous consequences, including death. Being vital for normal human functioning, it is critical that we maintain normal levels of these hormones. This occurs naturally in most individuals. However, some are not so fortunate and must administer synthetic replicas of these hormones in drug form, in order to normalize metabolism and maintain systematic homeostasis. Although most BB’rs possess normal levels of T3, many will supplement their natural production with exogenous versions of the drug, in order to capitalize on the enhanced fat burning effects which result from an increased metabolism.

In addition to fat loss, T3 also has other benefits which might interest a BB’r. Chief among them is its ability to increase protein synthesis. However, this effect is mild and is most cases will only manifest itself in muscle growth when utilizing lower dosages of around 25 mcg per day or less. While higher dosages will also stimulate protein synthesis, they generally result in excess energy demands being placed on the body, canceling out any increase in muscle growth which might have occurred. When it comes to amplifying the growth process through T3 administration, more is certainly not better. Still, variances in the number of calories consumed relative to caloric need, as well as differences in metabolic rate, make a “one size fits all” dosing approach impractical. While those with a slow metabolism might have no problem researching 100 mcg per day without incurring muscle loss, others may find that they begin to lose muscle tissue at only 50 mcg per day. When bodyfat reduction is the goal, as a general rule, most individuals should begin their research at between 25-50 mcg per day and move up from there as needed.

T3 also assists in up-regulating beta 2 receptors, which are the same receptors activated by drugs such as Clenbuterol and Ephedrine. When administered long-term, these products lead to receptor down-regulation, preventing them (or any other drug which attaches to these same receptor sites) from eliciting optimal effects through receptor signaling. While adequate time off will eventually remedy this problem, T3 will help stave off the down-regulation process, allowing us to effectively use Clen and related ilk for a longer period of time. Along the same lines, T3 can also be used to assist in reversing receptor down-regulation after the offending drugs have been discontinued. Last but not least, T3 stimulates the proliferation of IGF-1 levels, promoting anabolic effects within muscle tissue. This increase is rather minor, making it a compliment to the drug’s primary effects.
One concern which seems surface repeatedly is the drug’s suppressive effect on endogenous thyroid production and the body’s ability to recover this production post-use. Fortunately, many of the scare tactics used by well meaning individuals are nothing but a bunch of nonsense. I have read many claims which state that T3 causes long-term or even permanent shutdown of one’s natural thyroid production, yet I have not yet read a single clinical study, nor encountered a single situation in real life, where endogenous production was permanently sidelined. In reality, quite the opposite has been true, with recovery occurring rather quickly, even in some cases where the drug was discontinued after years of replacement therapy. While I do not advocate continuous usage, the claim that normal 6-8 week cycles will lead to severe and long-term suppression just aren’t true. Regardless, dosage and cycle length should always be determined by one’s needs.

In conclusion, T3 is one of the most formidable fat loss weapons in our arsenal, capable of obliterating bodyfat and transforming the physique in relatively short order, yet this compound needs to be respected. Otherwise, the lifter runs the chance of experiencing unwanted side effects. When administered correctly, T3 remains a safe and effective alternative to the stimulant-based drugs so popular in today’s marketplace, capable of accommodating the goals is BB’rs, fitness enthusiasts, and the body-conscious individual alike.

Tuesday, July 8, 2014

WHAT AN ESTER IS, AND HOW IT WORKS

If you have taken an interest in anabolic steroids you have noticed the similarities on the labeling of many drugs. Let's look at testosterone for example. One can find compounds like testosterone cypionate, enanthate, propionate, heptylate; caproate, phenylpropionate, isocaproate, decanoate, acetate, the list goes on and on. In all such cases the parent hormone is testosterone, which had been modified by adding an ester (enanthate, propionate etc.) to its structure. The following question arises: What is the difference between the various esterified versions of testosterone in regards to their use in bodybuilding?

An ester is a chain composed primarily of carbon and hydrogen atoms. This chain is typically attached to the parent steroid hormone at the 17th carbon position (beta orientation), although some compounds do carry esters at position 3 (for the purposes of this article it is not crucial to understand the exact position of the ester). Esterification of an injectable anabolic/androgenic steroid basically accomplishes one thing, it slows the release of the parent steroid from the site of injection. This happens because the ester will notably lower the water solubility of the steroid, and increase its lipid (fat) solubility. This will cause the drug to form a deposit in the muscle tissue, from which it will slowly enter into circulation as it is picked up in small quantities by the blood. Generally, the longer the ester chain, the lower the water solubility of the compound, and the longer it will take to for the full dosage to reach general circulation.

Slowing the release of the parent steroid is a great benefit in steroid medicine, as free testosterone (or other steroid hormones) previously would remain active in the body for a very short period of time (typically hours). This would necessitate an unpleasant daily injection schedule if one wished to maintain a continuous elevation of testosterone. By adding an ester, injections can be as infrequent as once per week or longer, instead of having to constantly re-administer the drug to achieve the desried effect. Clearly without the use of an ester, maintaining constant blood levels with an injectable anabolic/androgen would be much more difficult.

Esterification temporarily deactivates the steroid molecule. With a chain blocking the 17th beta position, binding to the androgen receptor is not possible (it can exert no activity in the body). In order for the compound to become active the ester must therefore first be removed. This automatically occurs once the compound has filtered into blood circulation, where esterase enzymes quickly cleave off (hydrolyze) the ester chain. This will restore the necessary hydroxyl (OH) group at the 17th beta position, enabling the drug to attach to the appropriate receptor. Now and only now will the steroid be able to have an effect on skeletal muscle tissue.

You can start to see why considering testosterone cypionate much more potent than enanthate makes little sense, as your muscles are seeing only free testosterone no matter what ester was used to deploy it.


ACTIONS OF DIFFERENT ESTERS

There are many different esters that are used with anabolic/androgenic steroids, but again, they all do basically the same thing. Esters vary only in their ability to reduce a steroid's water solubility. An ester like propionate for example will slow the release of a steroid for a few days, while the duration will be up to 15 days+/- with a decanoate ester. Esters have no effect on the tendency for the parent steroid to convert to estrogen or DHT (dihydrotestosterone: a more potent metabolite) nor will it effect the overall muscle-building potency of the compound. Any differences in results and side effects that may be noted by bodybuilders who have used various esterified versions of the same base steroid are just issues of timing.

*Testosterone enanthate causes estrogen related problems more readily than Sustanon, simply because with enanthate testosterone levels will peak and trough much sooner. Likewise testosterone suspension is the worst in regards to gyno and water bloat because blood hormone levels peak so quickly with this drug (propionate included). Instead of waiting weeks for testosterone levels to rise to their highest point, here we are at most looking at a couple of days. Given an equal blood level of testosterone, there would be no difference in the rate of aromatization or DHT conversion between different esters. There is simply no mechanism for this to be possible.

There is however one way that we can say an ester does technically effect potency; it is calculated in the steroid weight. The heavier the ester chain, the greater is its percentage of the total weight. In the case of testosterone enanthate for example, 250mg of esterified steroid (testosterone enanthate) is equal to only 180mg of free testosterone. 70mgs out of each 250mg injection is the weight of the ester. If we wanted to be really picky, we could consider enanthate slightly MORE potent than cypionate (I know this goes against popular thinking) as its ester chain contains one less carbon atom (therefore taking up a slightly smaller percentage of total weight). Propionate would of course come out on top of the three, releasing a measurable (but not significant) amount more testosterone per injection than cypionate or enanthate.

IN CONCLUSION

While the advent of esters certainly constitutes an invaluable advance in the field of anabolic steroid medicine, clearly you can see that there is no magic involved here. Esters work in a well-understood and predictable manner, and do not alter the activity of the parent steroid in any way other than to delay its release. Although the lure surrounding various steroid products like testosterone cypionate, Sustanon, Omnadren etc. certainly makes for interesting conversation, realistically it just amounts to misinformation that the athlete would be better off ignoring. Testosterone is testosterone and anyone who is going to tell you one ester form of this (or any) hormone is much better than another one should do a little more research, and a lot less talking.

Tuesday, July 1, 2014

Test E, Deca and DBol: The Bulking Stack

The purpose of this article is to educate the amateur bodybuilder on the correct set up of a powerful traditional bulking cycle; Test e, Deca, and Dbol. The use of Deca and Dbol has been long hailed as the mighty bulking cycle. Traditionally used as an off season cycle, the stack will do a wonderful job of adding muscle mass and letting the user come in at a heavier weight when reaching their goal body fat when cutting.

TESTOSTERONE ENANTHATE:

I have said it a million times before and I will say it again, testosterone is king. It is the foundation in which all cycles are built upon. Running any compound without the use of testosterone will leave you with hormone levels that are similar to a females. Testosterone Enanthate is a slower acting ester. With a 7 to 10 day half-life, it requires a less frequent dosing schedule to reach and maintain stable blood levels making it the better choice for beginner steroid users who may not be too fond of needles and do not want to do every day or every other day injections. Properly used, the injection schedule should be every 3.5 days on Monday and Thursday of the week. Dosages for testosterone enanthate range from a minimum of 400mg a week to 800mg a week for the average steroid user and cycles should be a minimum of 10 weeks due to the amount of time it takes to reach peak levels. More advanced users have been known to go over 1000mg a week, but one should be aware that it takes a lot of cycle experience to get to those levels. Longer estered testosterones like testosterone enanthate are known to cause more estrogen/aromatization side effects due to higher peak values over the course of the cycle. Proper AI/SERM precautions should be taken.

DECA DURABOLIN:

Deca has been the go to compound for bulking in bodybuilding amongst steroid users for years. Deca is a 19-nor compound. Its made from the same cloth as trenbolone. Consequently, it also shares many of the same issues as Tren. Being a 19-nor, deca is liver toxic. It also does not aromatize very well, but will cause a rise in progestin levels. Due to its ability to rise progestin levels, deca is known for causing libido issues or “deca dick.” Proper progestin/anti-estrogen drugs should be used to make sure you keep you from experiencing libido issues. It also will shut down natural testotsterone almost immediately with the first dose. Deca has as strong affinity to the androgen receptor and does great as an anabolic; it will raise both nitrogen retention and igf levels. Water retention does become an issue on deca, but the proper progestin drugs should keep it at bay. Deca is also known to help joint issues by storing water in the connective tissues and inproving collagen synthesis/mineral content. Some use the drug in low dosages such therapeutic effects. The recommended proper dosage for Deca is between 400-600mg a week. Though the ester connected to deca has a longer half life, its safe to inject deca on the same schedule as test e and c. In theory, deca can be injected once a week, but twice a week is the gold standard. Due to the highly suppressive nature of deca, its recommended that hcg be ran with the cycle.

DIANABOL:

Dbol is traditionally found in pill form. Like winstrol, Dbol is a 17aa oral steroid. 17aa orals are made the way they are to survive the first pass at the liver. Unfortunately, this makes dbol highly liver toxic (almost as toxic as winny). Dbol will also cause hypertension (a raise in blood pressure) so proper monitoring of your blood pressure should be maintained. Dbol is not the best at binding with the androgen receptor and most its effects are secondary. Dbol will suppress natural testosterone production. Many who are new to steroid use will try to do a Dbol only cycle. When dbol suppresses your natural production your levels start looking more like a females. Therefore, it should always be ran in a cycle with testosterone as a base. Dbol is said to be as strong as anadrol, though most will not see the same effects due to unequal dosages. Dbol is known as a kick start compound in cycles. Its ability to add weight comes on quickly and many people use it in the first 6 weeks of their cycle. Dosages range from 20-100mg a day, though an amateur user should stick to under 50mg to start.

The Cycle:

OK, lets set up a cycle for a first time user of these compounds combined. Keep in mind this isn’t a beginners cycle and stacking multiple compounds that you haven’t used in the same cycle may cause side effect and leave you wondering what the source of the issue was.

    Testosterone Enanthate 300mg twice a week   Week 1-12steroid muscle stack
    Deca 200mg twice a week Week 1-12
    Dbol 30-50mg a day Week 1-6
    HCG 500iu a week (250iu twice a week) Week 1-12

Post Cycle Therapy

    Clomid 100/50/50/50
    Nolva 40/40/20/20