GenezaMeds.com

GenezaMeds.com

Thursday, August 21, 2014

Mechano Growth Factor MGF

MGF is a variant of IGF-1, an isoform that is particularly sensitive to muscle trauma (weight training) and is essential for repair and growth of new cells, similar in manner to IGF-1. What you need to know is MGF triggers new cell growth or hyperplasia in rat testing, and since we as bodybuilders fancy ourselves as lab rats, it is currently the in vogue peptide by top amateurs and pros.

Well all of this sounds great but what is the catch? This is where we reach a cross-road, a potential problem with MGF. As great as MGF has been in clinical trials and rat studies, the fact is that injected MGF has a half life of minutes. So how are you going to make this work, besides injecting every hour or so of your waking day? The answer lies in a little known molecule protection agent knows as PEGylation.

So what is or PEGylation? In simple terms it is the process of attaching one or more chains of a substance called polyethylene glycol (PEG) to a protein molecule such as IGF or in this case MGF. Since the body does not react to PEG, it helps provide a protective barrier around an attached protein so it can survive in the body longer. This is highly beneficial for systemic products that must survive repeated attacks by enzymatic exposure. PEG is an inert non-toxic substance that can provide protection to amine groups since they are flexible and allow attachment by bioengineered processes to the receptor bearing cell. Finally a quick explanation of polyethylene glycol; Any of a family of high molecular weight compounds that can be liquid or wax-like in consistency and are soluble in water and in many organic solvents.

Polyethylene glycol itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG.

PEGylation can improve dosing convenience of many small molecules by increasing bioavailability and reducing dosing frequency. PEGylation also increases the amount of time the cell sits at the target site. This can be both good and bad. It is good because it increases the drug concentration, and with a longer time at the site, there is more chance of uptake by the cell. The bad news is that while it is sitting at the cell, there is increased risk of damage by enzymes that attack the cell. This is a double-edge sword that is a necessary evil; you must protect the molecule but at the same time increase the risk factor of damage due to longer exposure times at the target cell. As a result of the increased time at the cell, the optimal drug concentration can be achieved with less frequent dosing; a significant benefit to bodybuilders who are usually using poly-pharmacy at its finest.

PEGylated MGF is systemic in nature, meaning that the method of administration is not important. Most people are using MGF in a fashion similar to IGF, meaning they inject the peptide intramuscularly in recently trained muscle groups, hoping for an increase in cell repair and proliferation of new cells. While this thinking is optimistic at best, there is no research that would support site specific injections being beneficial for localized growth. This is a myth that has purveyed aas and peptide use for years. At this time, the literature and lab studies support subcutaneous injection, using small gauge insulin syringes.

Obviously there are no human research trials at this time; the peptide is still in research phases. Bodybuilder use at this time is all by trial and error. One company that currently carries MGF has conducted their own research trials, using test participants from underground steroid boards who are providing feedback in weekly intervals. While this is hardly a controlled environment and may have to many variables to accurately assess the product, at least it is a start.

I have also been conducting my own research, on myself and my clients, who often refer to themselves as Gavin's guinea pigs. As with most peptides, more is not better. Smaller doses with less frequent injection schedules have proven to be optimal. I personally have been using 200mcg injected sub-q, two times per week. I have had my clients try 100mcg, two times per week, three times per week, daily, etc. So far the best results have been my personal method, 200mcg, two times per week.

Elite athletes are experiencing incredible body fat loss, increased pumps, fullness, and vascularity. I was able to gain 6 pounds of lean mass and lose 4.2% body fat in 4 weeks of use. I kept using it for weeks 5 and 6 but with no further gains or body fat loss. It seems that MGF stalls out at the 4 week mark, my theory being that much like with media grade IGF-1 LR3, the cells reach super saturation and cannot process any further uptake of the peptide sequence. It is possible to bypass this saturation, but it will take some time to work out the differential nature of the timing, much like I had to do with IGF-1 LR3, where I have now found ways to take it for up to 20 weeks with little to no cell down-regulation.

At this time all use and injection schedules are by word of mouth, sometimes by erroneous information on underground boards. Proper use of MGF is merely by speculation; it will take some time to sort out the best method of administration, although with the ever changing world of science, where nothing ever stands still, it may take years to sort out optimal dosing schedules. Even with such stable peptide structures as growth hormone that have had years of research, new information is always being studied, and I speculate that it will with all peptides.

30 comments:

  1. PEGylation is the process of attachment between polyethylene glycol polymer chains and molecules such as drugs, therapeutic proteins or vesicles. peg linkers

    ReplyDelete
  2. After exploring a few of the blog posts on your site, I seriously appreciate your way of blogging. I added it to my bookmark site list and will be checking back soon. Please check out my web site as well and let me know what you think.
    buy mgf peg

    ReplyDelete
  3. Travel Photography Ideas

    EVERY LOCATION ALL OF US go to offers its specific appear, personality, as well as atmosphere. In the traveling photography event that we would like pictures in our moves to become great as well as enduring, they ought to catch many of these characteristics, as well as state just as much in regards to a location because provide the literal appear from it’s a Travel Photography.

    We're not likely in order to lengthy keep in mind the actual odor as well as hype of the blossom backyard within springtime, the actual travel photography with photographer amazement associated with looking with regard to the very first time in the hill all of us plan to travel photograph, the actual caress of the exotic air flow, the actual excitement of the large roller coaster, the sweetness in our very first crazy keep, or even the actual adrenaline associated with rafting whitened drinking water. The pictures have to provide these types of along traveling photographer with other feelings back again, in order to bring about the reminiscences, and also to connect the way you experienced in order to other people. To get this done, we have to believe as well as really feel around appear whenever aiming to create pictures . traveling photographer how to become a travel? It’s really difficult to capture travel photos to be a photographer.

    First of all, consider exactly what created you choose, of all the locations on the planet, to select this specific location. What ever this is—the seaside, the actual trips, the actual hill, the actual art galleries, the actual food—obviously you like. In the event that this did not, how to become a travel as a photographer, as a person would not end up being heading presently there. Which website or even exercise (or inactivity) is among the points you need to picture for traveller. However you will find most likely a number of other fascinating facets of the area you might not be familiar with. That is exactly where investigation is available in travel photography courses travelling in the world.

    ReplyDelete
  4. Three forms of home security from technology to preventative home maintenance.
    Website

    ReplyDelete

  5. Morphine is a pain medication of the opiate family which is found naturally in a number of plants and animals. It acts directly on the central nervous system (CNS) to decrease the feeling of pain. It can be taken for both acute pain and chronic pain. It is frequently used for pain from myocardial infarction and during labor.

    Visit Now: https://www.concretechemsonline.com

    ReplyDelete
  6. Domino99 merupakan situs bandarq online yang sudah banyak digemari oleh kalangan anak muda mau pun orang tua sebagai situs agen judi poker online. Bermain Domino99 pada situs bandarq terpercaya sangatlah seru dan bisa juga mendapatkan keuntungan besar. Namun tidak banyak situs bandarq online terpercaya yang asli, maka itu kami sarankan berhati-hati memilih agen bandarq online. Untuk para pencinta judi poker tidak perlu khawatir lagi untuk bermain poker online terpercaya melalui internet karena kini telah hadir agen bandarq online menyediakan permainan judi poker online terpercaya serta terbaik

    ReplyDelete

  7. Being cute is a way of life for this lively charmer. The Shih Tzu is known to be especially affectionate with children. As a small dog bred to spend most of their day inside royal palaces, they make a great pet if you live in an apartment or lack a big backyard.
    well trained Shih Tzu puppies for sale

    ReplyDelete
  8. QQMEGA368 Merupakan situs judi slot online dan bandar bola Terpercaya Penyedia Permainan Terlengkap Poker Online, Judi Slot Online, Poker Online, Casino Online Menggunakan Sistem Terbaik.

    ReplyDelete
  9. Great post however I was wanting to know if you
    could write a litte more on this topic? I’d be very grateful if you could elaborate a little bit more.
    Thanks!buy suboxone 8mg/2mg online denmark

    ReplyDelete
  10. This article presents clear idea designed for the new users of blogging, that truly how to do running
    a blog.
    how and where to order dankwoods online

    ReplyDelete
  11. skipthegames is best adult alternatives classified for backpage, yesbackpage, bedpage, leolist, cityxguide, adultsearch, skipthegames, megapersonal, tinder.

    The Games, as in "no foreplay, right to the action"? If you are anything like me, then you also get sick just sitting on your computer, fapping all day. There’s only so long that masturbation can sustain you during a dry spell. A man has needs, needs that porn sometimes can’t satisfy. Needs that no amount of pocket pussies or special lubricants can ever come close to relieving. Sometimes you just need the real thing, so how can skipthegames.com help with that?

    Okay, so you’ve decided that you’ve reached the point of no return. Your horniness levels are through the roof, and only one thing is going to solve it: some good old fashioned, real-life pussy. But maybe you don’t have the time to go out to the bars and try your luck. Or perhaps you’re sick and tired of playing the game of online dating with Tinder or OkCupid (sometimes trying to fuck on dating apps can require the same level of time and effort as trying to go out and get laid anyway).

    ReplyDelete
  12. This new classified site may be a free website for our users as backpage alternatives. Our aim is to modify each business owner to attach with consumers and sellers on-line. you'll post your advert for any price, from cars to physics, from article of furniture to article of clothing, and far a lot of. Submit ads freed from value by simply making an associate degree account begin advertising within the only method at Backpage alternatives
    www.thehidelist.com

    ReplyDelete
  13. Best Brooklyn SEO
    Local business visibility free report, website search engine optimization analytics. Looking for the best SEO companies in Brooklyn? We are web development company with marketing in mind. Website optimization, keywords research and ranking, technical SEO, on page and off page search engine optimization.


    ReplyDelete

  14. ullu web series download
    Watch Latest Web Series, Originals & Movies in HD Online. Choose from Genres like Thriller, Action, Adult, Comedy, Family Drama & more in multiple languages

    ReplyDelete
  15. livcrush

    The best random video chat with girls​
    Start a unique webcam random Video chat with girls right now! Thousands of beautiful strangers are waiting for you online!

    ReplyDelete
  16. Schlafprobleme
    Du leidest an Schlafproblemen und möchtest endlich effektiv dagegen ankämpfen So funktioniert es!

    ReplyDelete
  17. Welcome to the official informative website of GST admission 2020-21. Education ministry and public University authority has come to a point that they are going to arrange admission test in cluster method. This Central admission system is valid only for this year. Please visit here for important information.GST Admission Result 2021

    ReplyDelete
  18. I am continually amazed by the amount of information available on this subject.What you presented was well researched and well worded in order to get your stand on this across to all your readers custom patches .

    ReplyDelete
  19. joker gaming
    Joker Gaming ผู้ให้บริการเกมคาสิโนออนไลน์บนมือถือที่ดีที่สุด โจ๊กเกอร์เกม ขนความสนุกตื่นเต้นเร้าใจให้ท่านเลือกมากกว่า 100 เกม มาพร้อมเกมยอดนิยมอย่าง เกมยิงปลา ให้บริการตลอด 24 ชั่วโมง

    ReplyDelete
  20. This comment has been removed by the author.

    ReplyDelete
  21. joker gaming

    Joker Slot เกมสล็อตออนไลน์ เว็บไซต์อันดับต้นๆในประเทศไทย เว็บไซต์เราคือผู้ให้บริการจาก Joker123 อย่างที่ทางการ ที่กำลังได้รับความนิยมอย่างหนักในขนาดนี้ จากค่ายยักใหญ่จากต่างประเทศอย่าง Joker Game ปัจจุบันได้มีการอัพเกรดเป็นเวอร์ชั่นมาอย่างมากมาย จนมาให้เราได้เล่นในรูปแบบของ สล็อตออนไลน์ Joker Gaming มีทั้งรูปแบบการเล่นที่หลากหลายสลับกันไปไม่ว่าจะเป็น เกมสล็อต เกมยิงปลา และอีกหลายๆอย่างที่ทางทีมงาน ได้นำมามอบให้สมาชิกชอบแนวไหนก็เข้ามาเลือกได้เลย มีให้ท่านได้ ทดลองเล่นฟรี เบทเริ่มต้นเพียงแค่ 50 บาทเท่านั้นก็สามารถลุ้นรับรางวัลใหญ่ได้แล้วมีเกม sexygame66 ด้วยนะ

    ReplyDelete
  22. Classic Rock
    We are the top hipy hop vinyl sellers in USA If you are looking to buy hip hop vinyl records online in USA then you are at the right place.

    ReplyDelete
  23. all arabic news

    An in depth coverage of local global breaking news offering live reports on the latest political, economic, social, and cultural affairs only on Al Arabiya

    ReplyDelete
  24. bd today news

    Find the latest breaking news and information on the top stories, weather, business, entertainment, politics, and more For in depth coverage, Bd Portal 24 provides special reports, video, audio, photo galleries, and interactive guides

    ReplyDelete
  25. Thanks for taking the time to discuss this, I feel strongly about it and love learning more on this topic. If possible, as you gain expertise, would you mind updating your blog with extra information? It is extremely helpful for me. custom tambourine

    ReplyDelete
  26. Downtown Dentist

    Our Richmond Street W. dental clinic in Downtown Toronto has helped countless patients from all over the city, including Alexandra Park, Chinatown, Baldwin Village, Trinity – Bellwoods, CityPlace, Entertainment District, and the surrounding areas. Book an appointment today if you are looking for a reliable and affordable downtown general and cosmetic dentist.

    ReplyDelete
  27. The deep web includes all pages that are not indexed by search engines. This includes pages behind paywalls, password protected information, and closed intranets. The deep web includes personal information that you have access to through your bank's website.

    deep web

    ReplyDelete